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KMID : 0369819750050030358
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Jorunal of Korean Pharmaceutical Sciences
1975 Volume.5 No. 3 p.358 ~ p.365
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Studies on the Effect of Microfine Cellulose upon the Preparation of Prednisolone Tablets by Direct Compression Method
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옥수정/Ok SJ
용재익/Yong JI
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Abstract
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In the preparation of prednisolone tablets, when microfine cellulose$(Elcema^{\circledR})$ 수식 이미지 was used as diluents, stability and physical characteristics of prednisolone tablets are as follows; 1. Weight of the plain $Elcema^{\circledR}$ 수식 이미지 tablets increased by 75% of relative humidity and hardness was weakend, but the temperature $(60^{\circ}C)$ 수식 이미지 caused no change of thickness and decreased the weight and hardness. 2. In experimental tableting of prednisolone tablets, the addition of $Elcema^{\circledR}$ 수식 이미지 caused no difficulty in direct compression method, and the shortening of the disintegration time and increase of the hardness were satisfactory. 3. Dissolution rate test exhibited the result similiar to disintegration test. 4. In the comparison test of $Elcema^{\circledR}$ 수식 이미지 and $Avicel^{\circledR}$ 수식 이미지 as adjuvants the physical constants of prednisolone tablets showed nearly a similar tendency.
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KEYWORD
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